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Exploring the causal effect of maternal pregnancy adiposity on offspring adiposity: Mendelian randomisation using polygenic risk scores by Tom A. Bond; Rebecca C. Richmond; Ville Karhunen; Gabriel Cuellar-Partida; Maria Carolina Borges; Verena Zuber; Alexessander Couto Alves; Dan Mason; Tiffany C. Yang; Marc J. Gunter; Abbas Dehghan; Ioanna Tzoulaki; Sylvain Sebert; David M. Evans; Alex M. Lewin; Paul F. O’Reilly; Deborah A. Lawlor; Marjo-Riitta Järvelin is a Medicine article available to read on EtoBox.

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## Abstract ## Background Greater maternal adiposity before or during pregnancy is associated with greater offspring adiposity throughout childhood, but the extent to which this is due to causal intrauterine or periconceptional mechanisms remains unclear. Here, we use Mendelian randomisation (MR) with polygenic risk scores (PRS) to investigate whether associations between maternal pre-/early pregnancy body mass index (BMI) and offspring adiposity from birth to adolescence are causal. ## Methods We undertook confounder adjusted multivariable (MV) regression and MR using mother-offspring pairs from two UK cohorts: Avon Longitudinal Study of Parents and Children (ALSPAC) and Born in Bradford (BiB). In ALSPAC and BiB, the outcomes were birthweight (BW; N = 9339) and BMI at age 1 and 4 years (N = 8659 to 7575). In ALSPAC only we investigated BMI at 10 and 15 years (N = 4476 to 4112) and dual-energy X-ray absorptiometry (DXA) determined fat mass index (FMI) from age 10–18 years (N = 2659 to 3855). We compared MR results from several PRS, calculated from maternal non-transmitted alleles at between 29 and 80,939 single nucleotide polymorphisms (SNPs). ## Results MV and MR consistently show

Who reads Exploring the causal effect of maternal pregnancy adiposity on offspring adiposity: Mendelian randomisation using polygenic risk scores?

Author

Tom A. Bond; Rebecca C. Richmond; Ville Karhunen; Gabriel Cuellar-Partida; Maria Carolina Borges; Verena Zuber; Alexessander Couto Alves; Dan Mason; Tiffany C. Yang; Marc J. Gunter; Abbas Dehghan; Ioanna Tzoulaki; Sylvain Sebert; David M. Evans; Alex M. Lewin; Paul F. O’Reilly; Deborah A. Lawlor; Marjo-Riitta Järvelin

Publisher

Springer Science and Business Media LLC

Published

2022

Language

EN

Field

Medicine (Health Sciences)