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Can I read Genetic Evidence for a Large Overlap and Potential Bidirectional Causal Effects Between Resilience and Well-being on EtoBox?

Genetic Evidence for a Large Overlap and Potential Bidirectional Causal Effects Between Resilience and Well-being by de Vries, Lianne P. (author);Baselmans, Bart M.L. (author);Luykx, Jurjen J. (author);de Zeeuw, Eveline L. (author);Minică, Camelia C. (author);de Geus, Eco J.C. (author);Vinkers, Christiaan H. (author);Bartels, Meike (author) is a Neuroscience article available to read on EtoBox.

What is Genetic Evidence for a Large Overlap and Potential Bidirectional Causal Effects Between Resilience and Well-being about?

Resilience and well-being are strongly related. People with higher levels of well-being are more resilient after stressful life events or trauma and vice versa. Less is known about the underlying sources of overlap and causality between the constructs. In a sample of 11.304 twins and 2.572 siblings from the Netherlands Twin Register, we investigated the overlap and possible direction of causation between resilience (i.e. the absence of psychiatric symptoms despite negative life events) and well-being (i.e. satisfaction with life) using polygenic score (PGS) prediction, twin-sibling modelling, and the Mendelian Randomization Direction of Causality (MR-DoC) model. Longitudinal twin-sibling models showed significant phenotypic correlations between resilience and well-being (.41/.51 at time 1 and 2). Well-being PGS were predictive for both well-being and resilience, indicating that genetic factors influencing well-being also predict resilience. Twin-sibling modeling confirmed this genetic correlation (0.71) and showed a strong environmental correlation (0.93). In line with causality, both genetic (51%) and environmental (49%) factors contributed significantly to the covariance between

Who reads Genetic Evidence for a Large Overlap and Potential Bidirectional Causal Effects Between Resilience and Well-being?

It is typically read by researchers, students, and practitioners in Neuroscience.

Author
de Vries, Lianne P. (author);Baselmans, Bart M.L. (author);Luykx, Jurjen J. (author);de Zeeuw, Eveline L. (author);Minică, Camelia C. (author);de Geus, Eco J.C. (author);Vinkers, Christiaan H. (author);Bartels, Meike (author)
Publisher
Elsevier BV
Published
2021
Language
EN
Field
Neuroscience (Life Sciences)

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