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Age Specific and Attributable Risks of Familial Prostate Carcinoma from the Family-cancer Database by Kari Hemminki; Kamila Czene is a Medicine article available to read on EtoBox.

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## Abstract ## BACKGROUND Familial risks by proband status and age are useful for clinical counseling, and they can be used to calculate population‐attributable fractions (PAFs), which show the proportion of disease that could be prevented if the cause could be removed. ## METHODS The authors used the nationwide Swedish Family‐Cancer Database on 10.2 million individuals and 182,104 fathers and 3710 sons with medically verified prostate carcinoma to calculate age specific familial standardized incidence ratios (SIRs) with 95% confidence intervals (95%CI) and familial PAFs for prostate carcinoma in sons ages 0–66 years. ## RESULTS The incidence of prostate carcinoma was doubled between the years 1961 and 1998. The familial SIRs for prostate carcinoma were 2.38 (95%CI, 2.18–2.59) for men with prostate carcinoma in the father only, 3.75 (95%CI, 2.73–4.95) for men with prostate carcinoma in a brother only, and 9.44 (95%CI, 5.76–14.03) for men with prostate carcinoma in both a father and a brother. The corresponding familial PAFs were 8.86%, 1.78%, and 0.99%, respectively, yielding a total PAF of 11.63%. Age specific risks were shown for the same proband histories. The SIR was 8.05 for p

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Author

Kari Hemminki; Kamila Czene

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0008-543X)

Published

2002

Language

EN

Field

Medicine (Health Sciences)