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Lenalidomide, Bortezomib and Dexamethasone Induction Therapy for the Treatment of Newly Diagnosed Multiple Myeloma: a Practical Review by Georgia J. McCaughan; Sara Gandolfi; John J. Moore; Paul G. Richardson is a Medicine article available to read on EtoBox.

What is Lenalidomide, Bortezomib and Dexamethasone Induction Therapy for the Treatment of Newly Diagnosed Multiple Myeloma: a Practical Review about?

## Summary For patients with newly diagnosed multiple myeloma, survival outcomes continue to improve significantly: however, nearly all patients will relapse following induction treatment. Optimisation of induction therapy is essential to provide longer term disease control and the current standard of care for most patients incorporates an immunomodulatory agent and proteasome inhibitor, most commonly lenalidomide and bortezomib in combination with dexamethasone (RVD), with maintenance until progression. Historically there has been limited access to RVD as an induction strategy outside of the United States; fortunately, there is now increasing access worldwide. This review discusses the rationale for use of RVD as induction therapy and aims to provide guidance in prescribing this regimen in order to optimise efficacy while minimising the toxicities of treatment. We also highlight the increasing evidence for the utility of addition of a monoclonal antibody to the RVD backbone to deepen responses and potentially provide longer disease control.

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Author

Georgia J. McCaughan; Sara Gandolfi; John J. Moore; Paul G. Richardson

Publisher

Wiley

Published

2022

Language

EN

Field

Medicine (Health Sciences)