Can I read α-Globin loci in homozygous β-thalassemia intermedia on EtoBox?

α-Globin loci in homozygous β-thalassemia intermedia by P. Triadou; C. Lapoumeroulie; R. Girot; D. Labie is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is α-Globin loci in homozygous β-thalassemia intermedia about?

Homozygous beta-thalassemia intermediate (TI) differs from thalassemia major (TM) in being less severe clinically. Associated alpha-thalassemia could account for the TI phenotype by reducing the alpha/non-alpha chain imbalance. We have analyzed the alpha loci of 9 TI and 11 TM patients by restriction endonuclease mapping. All the TM and 7 of the TI patients have the normal complement of four alpha-globin genes (alpha alpha/alpha alpha). One TI patient has three alpha-globin genes (alpha alpha/-alpha), and another TI patient has five alpha genes (alpha alpha/alpha alpha alpha).

Who reads α-Globin loci in homozygous β-thalassemia intermedia?

Author

P. Triadou; C. Lapoumeroulie; R. Girot; D. Labie

Publisher

Springer; Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 0340-6717)

Published

1982

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)