Can I read Schizophrenia susceptibility gene locus at Xp22.3 on EtoBox?

Schizophrenia susceptibility gene locus at Xp22.3 by Jeff Milunsky; Xin‐Li Huang; Herman E Wyandt; Aubrey Milunsky is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Schizophrenia susceptibility gene locus at Xp22.3 about?

Multiple genetic loci have been implicated in the search for schizophrenia susceptibility genes, none having been proven as causal. Genetic heterogeneity is probable in the polygenic etiology of schizophrenia. We report on two unrelated Caucasian women with paranoid schizophrenia (meeting Diagnostic and Statistical Manual of Mental Disorders (DSM IV) criteria) who have an Xp22.3 overlapping deletion characterized by fluorescence __in situ__ hybridization (FISH). Patient 1 was previously reported by us (Wyandt HE, Bugeau‐Michaud L, Skare JC, Milunsky A. Partial duplication of Xp: a case report and review of previously reported cases. Amer J Med Genet 1991: 40: 280–283) to have a __de novo__ partial duplication of Xp. At that time, she was a 24‐year‐old woman with short stature, irregular menses, other abnormalities suggestive of Turner syndrome, and paranoid schizophrenia. Recently, FISH analysis demonstrated that she has an inverted duplication (X)(p22.1p11.2) and a microscopic deletion (X)(p22.2p22.3) between DXS1233 and DXS7108 spanning approximately 16–18 cM. Patient 2 is a 14‐year‐old girl with short stature, learning disabilities, and paranoid schizophrenia. High‐resolution ch

Who reads Schizophrenia susceptibility gene locus at Xp22.3?

Author

Jeff Milunsky; Xin‐Li Huang; Herman E Wyandt; Aubrey Milunsky

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0009-9163)

Published

1999

Language

LA

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)