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Can I read Analytical evaluation of the Abbott ARCHITECT Sirolimus assay on EtoBox?
Analytical evaluation of the Abbott ARCHITECT Sirolimus assay by G.T. Maine; S.E. Kahn; D. Vazquez; P. Meyer; D. Dickson; D. Kenney; M. Edwards; D.M. Haverstick is a Medicine article available to read on EtoBox.
What is Analytical evaluation of the Abbott ARCHITECT Sirolimus assay about?
Comparison against immunoassay (x) without and with urine extraction gave the following regression equations, respectively: LC-MS/MS = 0.24x -54 and LC-MS/MS = 0.72x -3. Concentrations of urinary free cortisol by LC-MS/MS were much lower than immunoassay (Advia Centaur) without urine extraction (10% of immunoassay values). When compared to immunoassay (Immulite 2000) with urine extraction the results were closer in value (67% of immunoassay values). Close correlation was found with an external lab's LC-MS/MS method. Normal individual results fell within reported literature reference ranges. Conclusion: LC-MS/MS is a more sensitive and specific method with a wider reportable range for urinary cortisol as compared with immunoassay. If immunoassay is to be used for urine free cortisol, prior solvent extraction is required.
Who reads Analytical evaluation of the Abbott ARCHITECT Sirolimus assay?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- G.T. Maine; S.E. Kahn; D. Vazquez; P. Meyer; D. Dickson; D. Kenney; M. Edwards; D.M. Haverstick
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0009-9120)
- Published
- 2008
- Language
- EN
- Field
- Medicine (Health Sciences)