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Leukocyte-Depleted PRP Preparation Methods by Ipank Cooler is a document available to read on EtoBox.
This document summarizes several studies examining genes regulated by the transcription factor MEIS1 that are important for platelet lineage and function. Chromatin immunoprecipitation followed by sequencing (ChIP-seq) in a megakaryocyte cell line identified over 13,000 MEIS1 binding sites near genes important for megakaryopoiesis and platelet biology. Dual luciferase reporter assays validated that MEIS1 directly regulates many of these genes. Analysis of platelet RNA found overexpression of 57 genes shown
- Author
- Ipank Cooler
- Language
- EN