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Palbociclib induces DNA damage and inhibits DNA repair to induce cellular senescence and apoptosis in oral squamous cell carcinoma by Tong-Hong Wang; Chin-Chuan Chen; Yann-Lii Leu; Yun-Shien Lee; Jang-Hau Lian; Hsi-Lung Hsieh; Chi-Yuan Chen is a Medicine article available to read on EtoBox.
What is Palbociclib induces DNA damage and inhibits DNA repair to induce cellular senescence and apoptosis in oral squamous cell carcinoma about?
## Background/purpose: Palbociclib is an fda-approved cyclin-dependent kinase (cdk) 4/6 inhibitor that has been clinically proven to be effective in breast cancer. however, its use in oral cancer is not well researched. in this study, we investigated the inhibitory activity of palbociclib against oral squamous cell carcinoma (oscc) cells and explored the mechanism of inhibition. ## Methods: The effects of palbociclib on the cytotoxicity of oscc cells were determined by mtt and colony formation assays. β-galactosidase staining and cell-cycle analysis were used to determine palbociclib-induced cellular senescence and apoptosis of oscc cells. wound healing and transwell assays were performed to assess the effects of palbociclib treatment on migration and invasion ability of oscc cells. whole transcriptome sequencing was conducted to show the relationship between dna damage repair of oscc cells and palbociclib treatment. palbociclib-induced dna damage and repair capacity of oscc cells were confirmed by comet assay and immunofluorescence confocal microscopy. western blotting was used to verify the palbociclib-mediated changes in the cdk/prb/c-myc/cdc25a pathway. finally, in vitro findin
Who reads Palbociclib induces DNA damage and inhibits DNA repair to induce cellular senescence and apoptosis in oral squamous cell carcinoma?
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- Author
- Tong-Hong Wang; Chin-Chuan Chen; Yann-Lii Leu; Yun-Shien Lee; Jang-Hau Lian; Hsi-Lung Hsieh; Chi-Yuan Chen
- Publisher
- Chinese Electronic Periodical Services; Elsevier ; Elsevier Singapore; Elsevier BV (ISSN 0929-6646)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)