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Cross-reactivity patterns of vaccinia-specific cytotoxic T lymphocytes from H-2K b mutants by Julia L. Hurwitz; Sueihua Pan; Peter J. Wettstein; Peter C. Doherty is a Immunology and Microbiology article available to read on EtoBox.

What is Cross-reactivity patterns of vaccinia-specific cytotoxic T lymphocytes from H-2K b mutants about?

Limit-dilution cultures were used to select vaccinia-immune T-cell populations from bml and bin3 mutant mice that were not lyric for virus-infected targets expressing the K b and Db MHC glycoprotein. Approximately 30% of virus-immune CTL were restricted in each case to K bml and K bin3, rather than to D b. Evidence of extensive cross-reactivity was found for these virus-immune CTL. Bin3 and bml 1 mice sharing one amino acid mutation from wild-type but differing by a second mutation seen only in bin3 are the most cross-reactive pair in their presentation of vaceinia. The bml and bmlO pair with dissimilar mutations from wild-type affecting the same CNBr fragment are also largely cross-reactive. However, 30% cross-reactivity is also found for bml and bin3, which differ in separate CNBr fragments. That mutants expressing amino acid substitutions in the same region of the peptide tend to show more evidence of cross-reactivity does not necessarily mean the T cells see linear arrays of amino acids on the MHC glycoprotein. For instance, K bin1 and K bmm differ for three amino acids, but bin1 T cells are highly lytic for bmIO virus-infected targets. However, there is no cross-reactivity for

Who reads Cross-reactivity patterns of vaccinia-specific cytotoxic T lymphocytes from H-2K b mutants?

Author

Julia L. Hurwitz; Sueihua Pan; Peter J. Wettstein; Peter C. Doherty

Publisher

Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC (ISSN 0093-7711)

Published

1983

Language

EN

Field

Immunology and Microbiology (Life Sciences)