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Can I read Early Cellular Brain Damage and Systemic Inflammatory Response After Cardiopulmonary Resuscitation or Isolated Severe Head Trauma: a Comparative Pilot Study on Common Pathomechanisms on EtoBox?
Early Cellular Brain Damage and Systemic Inflammatory Response After Cardiopulmonary Resuscitation or Isolated Severe Head Trauma: a Comparative Pilot Study on Common Pathomechanisms by Thomas Mussack; Peter Biberthaler; Cornelia Gippner-Steppert; Karl-Georg Kanz; Ernst Wiedemann; Wolf Mutschler; Marianne Jochum is a Medicine article available to read on EtoBox.
What is Early Cellular Brain Damage and Systemic Inflammatory Response After Cardiopulmonary Resuscitation or Isolated Severe Head Trauma: a Comparative Pilot Study on Common Pathomechanisms about?
Severe neurological deficits are common characteristics of patients surviving cardiopulmonary resuscitation (CPR) or isolated severe head trauma (SHT). For comparative evaluation of underlying pathomechanisms, 22 patients with out-of-hospital cardiac arrest and successful CPR as well as 10 patients with SHT were included in our prospective study. Circulating S-100B was determined as an indicator of cellular brain damage. , soluble E-selectin (sE-selectin) and polymorphonuclear (PMN-) elastase were measured as markers of systemic inflammation following whole body ischaemia and reperfusion injury. Venous blood samples were drawn on scene (median time 11.0 min after starting basic life support) and in the intensive care unit (median time 12.5 h thereafter) in CPR patients and at admission to hospital (median time 43.8 min after trauma) and approx. 12 h later in SHT patients. Biochemical parameters in these samples were compared with specimens taken from 20 healthy volunteers. Initial median S-100B levels of the CPR and SHT patients were both significantly increased compared with the controls. Twelve hours later, significant falls in S-100B revealed no differences between the two patie
Who reads Early Cellular Brain Damage and Systemic Inflammatory Response After Cardiopulmonary Resuscitation or Isolated Severe Head Trauma: a Comparative Pilot Study on Common Pathomechanisms?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Thomas Mussack; Peter Biberthaler; Cornelia Gippner-Steppert; Karl-Georg Kanz; Ernst Wiedemann; Wolf Mutschler; Marianne Jochum
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0300-9572)
- Published
- 2001
- Language
- EN
- Field
- Medicine (Health Sciences)