Can I read Role of DAMPs and cell death in autoimmune diseases: the example of multiple sclerosis on EtoBox?

Role of DAMPs and cell death in autoimmune diseases: the example of multiple sclerosis by Walter Gottlieb Land is a Immunology and Microbiology article available to read on EtoBox.

What is Role of DAMPs and cell death in autoimmune diseases: the example of multiple sclerosis about?

Multiple sclerosis is a chronic neuroinflammatory demyelinating disease of the central nervous system (CNS) of unknown etiology and still incompletely clarified pathogenesis. The disease is generally considered a disorder resulting from a complex interplay between environmental risk factors and predisposing causal genetic variants. To examine the etiopathogenesis of the disease, two complementary pre-clinical models are currently discussed: the "outside-in" model proposing a peripherally elicited inflammatory/ autoimmune attack against degraded myelin as the cause of the disease, and the "inside-out" paradigm implying a primary cytodegenerative process of cells in the CNS that triggers secondary reactive inflammatory/autoimmune responses against myelin debris. In this review, the integrating pathogenetic role of damage-associated molecular patterns (DAMPs) in these two scenario models is examined by focusing on the origin and sources of these molecules, which are known to promote neuroinflammation and, via activation of pattern recognition receptor-bearing antigen-presenting cells, drive and shape autoimmune responses. In particular, environmental factors are discussed that are con

Who reads Role of DAMPs and cell death in autoimmune diseases: the example of multiple sclerosis?

Author

Walter Gottlieb Land

Publisher

Springer Science and Business Media LLC

Published

2023

Language

EN

Field

Immunology and Microbiology (Life Sciences)