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A Conductive Bioengineered Cardiac Patch for Myocardial Infarction Treatment by Improving Tissue Electrical Integrity by Qi Yin; Ping Zhu; Wei Liu; Zhongbao Gao; Luming Zhao; Chunlan Wang; Siwei Li; Miaomiao Zhu; Qi Zhang; Xiao Zhang; Changyong Wang; Jin Zhou is a Engineering article available to read on EtoBox.
What is A Conductive Bioengineered Cardiac Patch for Myocardial Infarction Treatment by Improving Tissue Electrical Integrity about?
Conductive scaffolds are of great value for constructing functional myocardial tissues and promoting tissue reconstruction in the treatment of myocardial infarction (MI). Here, a novel scaffold composed of silk fibroin and polypyrrole (SP50) with a typical sponge-like porous structure and electrical conductivity similar to the native myocardium is developed. An electroactive engineered cardiac patch (SP50 ECP) with a certain thickness is constructed by applying electrical stimulation (ES) to the cardiomyocytes (CMs) on the scaffold. SP50 ECP can significantly express cardiac marker protein (α-actinin, Cx-43, and cTnT) and has better contractility and electrical coupling performance. Following in vivo transplantation, SP50 ECP shows a notable therapeutic effect in repairing infarcted myocardium. Not only can SP50 ECP effectively improves left ventricular remodeling and restore cardiac functions, such as ejection function (EF), but more importantly, improves the propagation of electrical pulses and promote the synchronous contraction of CMs in the scar area with normal myocardium, effectively reducing the susceptibility of MI rats to arrhythmias. In conclusion, this study demonstrate
Who reads A Conductive Bioengineered Cardiac Patch for Myocardial Infarction Treatment by Improving Tissue Electrical Integrity?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Qi Yin; Ping Zhu; Wei Liu; Zhongbao Gao; Luming Zhao; Chunlan Wang; Siwei Li; Miaomiao Zhu; Qi Zhang; Xiao Zhang; Changyong Wang; Jin Zhou
- Publisher
- Wiley
- Published
- 2022
- Language
- EN
- Field
- Engineering (Physical Sciences)