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Admission Systolic Blood Pressure and Effect of Endovascular Treatment in Patients with Ischaemic Stroke: an Individual Patient Data Meta-analysis by Noor Samuels; Rob A van de Graaf; Maxim J H L Mulder; Scott Brown; Bob Roozenbeek; Pieter Jan van Doormaal; Mayank Goyal; Bruce C V Campbell; Keith W Muir; Nelly Agrinier; Serge Bracard; Phil M White; Luis San Román; Tudor G Jovin; Michael D Hill; Peter J Mitchell; Andrew M Demchuk; Alain Bonafe; Thomas G Devlin; Adriaan C G M van Es; Hester F Lingsma; Diederik W J Dippel; Aad van der Lugt is a Medicine article available to read on EtoBox.

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Background Current guidelines for ischaemic stroke treatment recommend a strict, but arbitrary, upper threshold of 185/110 mm Hg for blood pressure before endovascular thrombectomy. Nevertheless, whether admission blood pressure influences the effect of endovascular thrombectomy on outcome remains unknown. Our aim was to study the influence of admission systolic blood pressure (SBP) on functional outcome and on the effect of endovascular thrombectomy. Methods We used individual patient data from seven randomised controlled trials (MR CLEAN, ESCAPE, EXTEND-IA, SWIFT PRIME, REVASCAT, PISTE, and THRACE) that randomly assigned patients with anterior circulation ischaemic stroke to endovascular thrombectomy (predominantly using stent retrievers) or standard medical therapy (control) between June 1, 2010, and April 30, 2015. We included all patients for whom SBP data were available at hospital admission. The primary outcome was functional outcome (modified Rankin Scale) at 90 days. We assessed the association of SBP with outcome in both the endovascular thrombectomy group and the control group using multilevel regression analysis and tested for non-linearity and for interaction between S

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Author

Noor Samuels; Rob A van de Graaf; Maxim J H L Mulder; Scott Brown; Bob Roozenbeek; Pieter Jan van Doormaal; Mayank Goyal; Bruce C V Campbell; Keith W Muir; Nelly Agrinier; Serge Bracard; Phil M White; Luis San Román; Tudor G Jovin; Michael D Hill; Peter J Mitchell; Andrew M Demchuk; Alain Bonafe; Thomas G Devlin; Adriaan C G M van Es; Hester F Lingsma; Diederik W J Dippel; Aad van der Lugt

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Medicine (Health Sciences)