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Botulinum Toxin A in the Management of Pediatric Sialorrhea: A Systematic Review by Tiffany Heikel; Shivam Patel; Kasra Ziai; Sejal J. Shah; Jessyka G. Lighthall is a Medicine article available to read on EtoBox.

What is Botulinum Toxin A in the Management of Pediatric Sialorrhea: A Systematic Review about?

## Objective: Botulinum toxin A is known to be effective and safe in managing sialorrhea in pediatric patients; however, there is no consensus on a protocol for optimal injection sites and appropriate dosing for injection. ## Methods: This review was performed using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocol. PubMed, EMBASE, and other databases were queried to identify articles that evaluated botulinum toxin type A for the treatment of sialorrhea in the pediatric population. A total of 405 studies were identified. After applying inclusion and exclusion criteria, 31 articles were included for review. ## Results: A total of 14 studies evaluated 2-gland injections, and 17 studies evaluated 4-gland injections. Of the 31 studies included, one study assessed incobotulinumtoxinA (Xeomin^®^) the remaining all used onabotulinumtoxinA (Botox^®^). For 2-gland injection studies, a combined total of 899 participants were reviewed, where 602 participants received 50 units into their submandibular glands, while 262 participants received 30 to 50 units. Among 4-gland injection studies, there was a combined total of 388 participants, with the most prevalent dosa

Who reads Botulinum Toxin A in the Management of Pediatric Sialorrhea: A Systematic Review?

Author

Tiffany Heikel; Shivam Patel; Kasra Ziai; Sejal J. Shah; Jessyka G. Lighthall

Publisher

SAGE Publications

Published

2022

Language

EN

Field

Medicine (Health Sciences)