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Prognostic Implications of Novel Ten-Gene Signature in Uveal Melanoma by Luo, Huan; Ma, Chao; Shao, Jinping; Cao, Jing is a Medicine article available to read on EtoBox.

What is Prognostic Implications of Novel Ten-Gene Signature in Uveal Melanoma about?

Uveal melanoma (UM) is the most common primary intraocular cancer in adults. Genomic studies have provided insights into molecular subgroups and oncogenic drivers of UM that may lead to novel therapeutic strategies. Dataset TCGA-UVM, download from TCGA portal, were taken as the training cohort, and dataset GSE22138, obtained from GEO database, was set as the validation cohort. In training cohort, Kaplan-Meier analysis and univariate Cox regression model were applied to preliminary screen prognostic genes. Besides, the Cox regression model with LASSO was implemented to build a multi-gene signature, which was then validated in the validation cohorts through Kaplan-Meier, Cox, and ROC analyses. In addition, the correlation between copy number aberrations and risk score was evaluated by Spearman test. GSEA and immune infiltrating analyses were conducted for understanding function annotation and the role of the signature in the tumor microenvironment. A ten-gene signature was built, and it was examined by Kaplan-Meier analysis revealing that significantly overall survival, progression-free survival, and metastasis-free survival difference was seen. The ten-gene signature was further pro

Who reads Prognostic Implications of Novel Ten-Gene Signature in Uveal Melanoma?

Author

Luo, Huan; Ma, Chao; Shao, Jinping; Cao, Jing

Publisher

Frontiers Media SA; Frontiers Media S.A.; Lausanne: Frontiers Media S.A., 2011- (ISSN 2234-943X)

Published

2020

Language

EN

Field

Medicine (Health Sciences)