Opening book details…
Can I read The genetic structure of Neisseria meningitidis populations in Cuba before and after the introduction of a serogroup BC vaccine on EtoBox?
The genetic structure of Neisseria meningitidis populations in Cuba before and after the introduction of a serogroup BC vaccine by Yanet Climent; Rachel Urwin; Daniel Yero; Isabel Martinez; Alejandro Martín; Franklin Sotolongo; Martin C.J. Maiden; Rolando Pajón is a Medicine article available to read on EtoBox.
What is The genetic structure of Neisseria meningitidis populations in Cuba before and after the introduction of a serogroup BC vaccine about?
We investigated the population genetics in collections of meningococci sampled in Cuba during the period 1983-2005, thereby covering a period before and after the introduction of an antimeningococcal B-C vaccine. A total of 163 case isolates and 210 isolates from healthy carriers were characterized by multilocus sequence typing (MLST) and sequence determination of porA, porB and fetA genes. A total of 56 sequence types (STs) including 28 new STs were identified among these isolates. The analysis of surface antigens revealed variants 3-1 and 3-8 to be prevalent for porB; variant F5-1 was the most common FetA epitope, and variants 19 and 15 corresponded to the prevalent variable regions 1 (VR1) and VR2 PorA epitopes, respectively. The strongest associations between specific surface protein variants and clonal complexes were detected in lineages ST-32 and ST-53. All ST-32 complex isolates possessed porB3 alleles, and the most frequent antigen combination among ST-32 complex isolates was P1.19,15;F5-1. Variants PorB3-64 at PorB and P1.30 at PorA VR2, in combination with the PorA VR1 variants P1.12-1, P1.7 and P1.7-2 as well as the FetA variants F1-2 and F1-7, dominated the ST-53 comple
Who reads The genetic structure of Neisseria meningitidis populations in Cuba before and after the introduction of a serogroup BC vaccine?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Yanet Climent; Rachel Urwin; Daniel Yero; Isabel Martinez; Alejandro Martín; Franklin Sotolongo; Martin C.J. Maiden; Rolando Pajón
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 1567-1348)
- Published
- 2010
- Language
- EN
- Field
- Medicine (Health Sciences)