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Coagulation factor XIII polymorphisms and the risk of myocardial infarction and ischaemic stroke in young women by Alexander P. Reiner; Michele B. Frank; Stephen M. Schwartz; Michael L. Linenberger; W. T. Longstreth Jr; Gayle Teramura; Frits R. Rosendaal; Bruce M. Psaty; David S. Siscovick is a Medicine article available to read on EtoBox.
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**Summary.** The inconsistent findings among association studies that have examined the relationship between factor XIIIA Val34Leu and thrombosis may be owing to (1) population differences in the prevalence of other risk factors that modify the association with Val34Leu, or (2) linkage disequilibrium with other functional factor XIIIA polymorphisms. We therefore performed genotyping for factor XIIIA Val34Leu, Tyr204Phe and Pro564Leu in a population‐based study of myocardial infarction (MI) and ischaemic stroke among white women < 45‐years of age and 345 demographically similar controls, and examined potential interactions with other risk factors. The presence of the factor XIIIA Leu34 allele was associated with a slight decreased risk of MI [odds ratio (OR) = 0·80] that was most pronounced among women with traditional cardiovascular risk factors. Paradoxically, women carrying two copies of the Leu34 allele had a nearly fourfold increased risk of ischaemic stroke relative to the Val34/Val34 genotype. Heterozygosity for factor XIIIA Phe204 was associated with a milder increased risk of ischaemic stroke, and analysis of a kindred with congenital dysfibrinogenaemia suggested that co‐in
Who reads Coagulation factor XIII polymorphisms and the risk of myocardial infarction and ischaemic stroke in young women?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Alexander P. Reiner; Michele B. Frank; Stephen M. Schwartz; Michael L. Linenberger; W. T. Longstreth Jr; Gayle Teramura; Frits R. Rosendaal; Bruce M. Psaty; David S. Siscovick
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0007-1048)
- Published
- 2002
- Language
- EN
- Field
- Medicine (Health Sciences)