Can I read A Predict Model to Evaluate the Level of HBV-DNA for the Patients With Chronic Hepatitis B Virus (CHB) in Clinic: a Cross-sectional Study on EtoBox?

A Predict Model to Evaluate the Level of HBV-DNA for the Patients With Chronic Hepatitis B Virus (CHB) in Clinic: a Cross-sectional Study by Zheng, Jinli (author);Wan, Juan (author);Jiang, Chenhao (author);Huang, Yang (author);Pu, Xingyu (author);Jiang, Li (author) is a scholarly article available to read on EtoBox.

What is A Predict Model to Evaluate the Level of HBV-DNA for the Patients With Chronic Hepatitis B Virus (CHB) in Clinic: a Cross-sectional Study about?

## Abstract Background: The previous studies showed the correlation between HBsAg and serum HBV DNA levels were weak or missing. And the relationship of HBeAg and HBV DNA levels was lack.Objective: The study aims to investigate the correlation between HBeAg and HBV DNA levels, and to find an alternative tool to evaluate the HBV DNA levels for clinicians.Methods: We enrolled 1020 patients in this cross-sectional study. We divided the patients into four groups as: HBeAg positivity and negativity groups, high and low HBV DNA levels groups. Further, as to the levels of HBV DNA, we performed subgroups’ in HBeAg-positive and HBeAg-negative groups.Results: The levels of ALT, ALB and HBeAg were the independent factors for the serum HBV DNA in CHB patients. The predict model for the patients with HBeAg-positive was: M~1~ (high HBV DNA levels) = 1.412 × (1 for HBeAg-positive >16.15 S/CO or 0 for others) + 0.004 × (1 for ALT > 42.5 IU/L or 0 for others) −0.029 × (1 for ALB > 25.5 g/L or 0 for others) + 0.779, and the AUC was 0.606. And the predict model of patients with HBeAg-negative was: M~2~ (low levels of HBV DNA) = 0.385 − 0.005 × (1 for ALT > 36.5 IU/L or 0 for others) − 0.006 × (1 for

Author

Zheng, Jinli (author);Wan, Juan (author);Jiang, Chenhao (author);Huang, Yang (author);Pu, Xingyu (author);Jiang, Li (author)

Publisher

Research Square Platform LLC

Published

2021

Language

EN