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NADPH oxidases: Pathophysiology and therapeutic potential in age-associated pulmonary fibrosis by Kato, Kosuke; Hecker, Louise is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is NADPH oxidases: Pathophysiology and therapeutic potential in age-associated pulmonary fibrosis about?

Oxidative stress has been associated with a number of human fibrotic diseases, including idiopathic pulmonary fibrosis (IPF). Although oxidative stress is associated with both fibrosis and aging, the precise cellular sources(s) of reactive oxygen species (ROS) that contribute to the disease pathogenesis remain poorly understood. NADPH oxidase (Nox) enzymes are an evolutionarily conserved family, where their only known function is the production of ROS. A growing body of evidence supports a link between excessive Nox-derived ROS and numerous chronic diseases (including fibrotic disease), which is most prevalent among the elderly population. In this review, we examine the evidence for Nox isoforms in the pathogenesis of IPF, and the potential to target this enzyme family for the treatment of IPF and related fibrotic disorders. A better understanding of the Nox-mediated redox imbalance in aging may be critical to the development of more effective therapeutic strategies for age-associated fibrotic disorders. Strategies aimed at specifically blocking the source(s) of ROS through Nox inhibition may prove to be more effective as anti-fibrotic therapies, as compared to antioxidant approach

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Author

Kato, Kosuke; Hecker, Louise

Publisher

Elsevier ; Elsevier BV; Amsterdam: Elsevier (ISSN 2213-2317)

Published

2020

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)