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What is Rapid Intestinal Adaptation to High-Fat Diet about?
The study by Enriquez et al. investigates the rapid adaptation of the intestinal epithelium in response to a high-fat diet (HFD). Within one day of HFD exposure, mice exhibit significant metabolic changes and increased intestinal epithelial proliferation, with transcriptional shifts indicating enhanced fatty acid metabolism. By day three, progenitor cells show a shift towards absorptive lineage, and by day seven, enterocytes adapt to improve lipid absorption efficiency.
- Author
- felipe.nikt
- Language
- EN