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Activity of GH/IGF‐I axis in patients with dilated cardiomyopathy by Fabio Broglio; Alberto Fubini; Mara Morello; Emanuela Arvat; Gianluca Aimaretti; Laura Gianotti; Muny F. Boghen; Romano Deghenghi; Lucia Mangiardi; Ezio Ghigo is a Medicine article available to read on EtoBox.
What is Activity of GH/IGF‐I axis in patients with dilated cardiomyopathy about?
## OBJECTIVE There is evidence showing that GH and IGF‐I have specific receptors in the heart and that these hormones are able to promote cardiac remodelling and inotropism. It has been reported that patients with dilated cardiomyopathy (DCM) benefit from treatment with rhGH showing a striking increase in cardiac contractility. However, until now, the activity of GH/IGF‐I axis in DCM has never been clearly assessed. ## PATIENTS To clarify this point, we enrolled 39 patients with idiopathic or post‐ischaemic DCM (36 M/3 F; age (mean ± S.D.) 55.3 ± 9.0 years; BMI: 25.3 ± 3.2 kg/m^2^; New York Heart Association class (NYHA) I/2, II/19, III/15, IV/3) and 42 age‐matched controls (CS, 38 M/4 F; age 56.0 ± 7.8 years; BMI: 24.9 ± 1.5 kg/m^2^). DCM patients were characterized by a left‐ventricular diastolic diameter of 73.8 ± 8.3 mm, a shortening fraction of 15.9 ± 6.4% and a left ventricular ejection fraction of 25.1 ± 8.7%. In all subjects clinical and biochemical indices of renal and hepatic function as well as nutritional parameters were in the normal range. ## MEASUREMENTS In both groups we studied: a) IGF‐I levels in basal conditions and after administration of low rhGH doses for 4 da
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- Author
- Fabio Broglio; Alberto Fubini; Mara Morello; Emanuela Arvat; Gianluca Aimaretti; Laura Gianotti; Muny F. Boghen; Romano Deghenghi; Lucia Mangiardi; Ezio Ghigo
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 0300-0664)
- Published
- 1999
- Language
- EN
- Field
- Medicine (Health Sciences)