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Pharmacokinetics of Enrofloxacin in Newborn and One-week-old Calves by L. Kaartinen; S. PyÖrÄlÄ; M. Moilanen; S. RÄisÄnen is a Medicine article available to read on EtoBox.

What is Pharmacokinetics of Enrofloxacin in Newborn and One-week-old Calves about?

The pharmacokinetic behaviour of enrofloxacin was compared in four one‐day‐old and four one‐week‐old calves in order to find out if there were any age‐related differences. Mean volume of distribution (__V__~d(ss)~) and clearance (__Cl__) were significantly smaller in newborn calves: __V__~d(ss)~ was 1.8 and 2.3 L/kg, while clearance was 0.19 and 0.39 L/kg.h in newborn and one‐week‐old calves, respectively. Mean elimination half‐life (__t__~1/2β~) did not differ significantly in newborn and in one‐week‐old calves: mean __t__~1/2β~ was 6.6 h and 4.9 h, respectively. Enrofloxacin was metabolized to ciprofloxacin both by newborn and one‐week‐old calves, but the maximum concentration (__C__~max~) of ciprofloxacin was lower and the time when maximum concentration was reached (__t__~max~) later in newborn calves. We conclude that the dosage of enrofloxacin should be adjusted according to age when administered to very young calves.

Who reads Pharmacokinetics of Enrofloxacin in Newborn and One-week-old Calves?

Author

L. Kaartinen; S. PyÖrÄlÄ; M. Moilanen; S. RÄisÄnen

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0140-7783)

Published

1997

Language

EN

Field

Medicine (Health Sciences)