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Can I read 3D-Printed Microinjection Needle Arrays via a Hybrid DLP-Direct Laser Writing Strategy on EtoBox?
3D-Printed Microinjection Needle Arrays via a Hybrid DLP-Direct Laser Writing Strategy by Sunandita Sarker; Adira Colton; Ziteng Wen; Xin Xu; Metecan Erdi; Anthony Jones; Peter Kofinas; Eleonora Tubaldi; Piotr Walczak; Miroslaw Janowski; Yajie Liang; Ryan D. Sochol is a Engineering article available to read on EtoBox.
What is 3D-Printed Microinjection Needle Arrays via a Hybrid DLP-Direct Laser Writing Strategy about?
Microinjection protocols are ubiquitous throughout biomedical fields, with hollow microneedle arrays (MNAs) offering distinctive benefits in both research and clinical settings. Unfortunately, manufacturing-associated barriers remain a critical impediment to emerging applications that demand high-density arrays of hollow, high-aspect-ratio microneedles. To address such challenges, here, a hybrid additive manufacturing approach that combines digital light processing (DLP) 3D printing with “ex situ direct laser writing (__es__DLW)” is presented to enable new classes of MNAs for fluidic microinjections. Experimental results for __es__DLW-based 3D printing of arrays of high-aspect-ratio microneedles—with 30 μm inner diameters, 50 μm outer diameters, and 550 μm heights, and arrayed with 100 μm needle-to-needle spacing—directly onto DLP-printed capillaries reveal uncompromised fluidic integrity at the MNA-capillary interface during microfluidic cyclic burst-pressure testing for input pressures in excess of 250 kPa (__n__ = 100 cycles). Ex vivo experiments perform using excised mouse brains reveal that the MNAs not only physically withstand penetration into and retraction from brain tissu
Who reads 3D-Printed Microinjection Needle Arrays via a Hybrid DLP-Direct Laser Writing Strategy?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Sunandita Sarker; Adira Colton; Ziteng Wen; Xin Xu; Metecan Erdi; Anthony Jones; Peter Kofinas; Eleonora Tubaldi; Piotr Walczak; Miroslaw Janowski; Yajie Liang; Ryan D. Sochol
- Publisher
- Wiley
- Published
- 2023
- Language
- EN
- Field
- Engineering (Physical Sciences)