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Efficacy of probiotics on nonalcoholic fatty liver disease: A meta-analysis by Xiangyu Zhou; Jincheng Wang; Sufang Zhou; Jiajia Liao; Zuoyu Ye; Leiming Mao is a Medicine article available to read on EtoBox.

What is Efficacy of probiotics on nonalcoholic fatty liver disease: A meta-analysis about?

## Objectives: The intestinal flora is closely related to the pathogenesis of nonalcoholic fatty liver disease (NAFLD). This study intends to systematically evaluate the efficacy and safety of probiotics in the treatment of NAFLD through a meta-analysis of published randomized controlled trials. ## Methods: This study was conducted through a search of published randomized controlled trials using probiotic-related drugs for the treatment of nonalcoholic fatty liver disease (up to April 6, 2022). The JADAD evaluation table was used to evaluate the quality of the literatures included in the search, and the risk of bias was evaluated according to the Cochrane evaluation manual. Finally, RevMan5.4 software was used for meta-analysis. ## Results: A total of 21 randomized clinical trials involving 1037 patients with NAFLD were included in this study. Meta-analysis results showed that after probiotic intervention, liver function, blood lipid level, blood glucose levels and insulin levels were significantly reduced, which had a good effect on improving hepatic steatosis. However, it did not significantly improve BMI, inflammatory factors, or homeostasis model assessment of insulin resistanc

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Author

Xiangyu Zhou; Jincheng Wang; Sufang Zhou; Jiajia Liao; Zuoyu Ye; Leiming Mao

Publisher

Ovid Technologies (Wolters Kluwer Health)

Published

2023

Language

EN

Field

Medicine (Health Sciences)