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Pathogenic tau–induced transposable element–derived dsRNA drives neuroinflammation by Elizabeth Ochoa; Paulino Ramirez; Elias Gonzalez; Jasmine De Mange; William J. Ray; Kevin F. Bieniek; Bess Frost is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Pathogenic tau–induced transposable element–derived dsRNA drives neuroinflammation about?
Deposition of tau protein aggregates in the brain of affected individuals is a defining feature of “tauopathies,” including Alzheimer’s disease. Studies of human brain tissue and various model systems of tauopathy report that toxic forms of tau negatively affect nuclear and genomic architecture, identifying pathogenic tau–induced heterochromatin decondensation and consequent retrotransposon activation as a causal mediator of neurodegeneration. On the basis of their similarity to retroviruses, retrotransposons drive neuroinflammation via toxic intermediates, including double-stranded RNA (dsRNA). We find that dsRNA and dsRNA sensing machinery are elevated in astrocytes of postmortem brain tissue from patients with Alzheimer’s disease and progressive supranuclear palsy and in brains of tau transgenic mice. Using a __Drosophila__ model of tauopathy, we identify specific tau-induced retrotransposons that form dsRNA and find that pathogenic tau and heterochromatin decondensation causally drive dsRNA-mediated neurodegeneration and neuroinflammation. Our study suggests that pathogenic tau–induced heterochromatin decondensation and retrotransposon activation cause elevation of inflammatory
Who reads Pathogenic tau–induced transposable element–derived dsRNA drives neuroinflammation?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Elizabeth Ochoa; Paulino Ramirez; Elias Gonzalez; Jasmine De Mange; William J. Ray; Kevin F. Bieniek; Bess Frost
- Publisher
- American Association for the Advancement of Science (AAAS)
- Published
- 2023
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Physical Sciences)