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Soluble CD146 in the detection and grading of intravascular and tissue congestion in patients with acute dyspnoea: analysis of the prospective observational Lithuanian Echocardiography Study of Dyspnoea in Acute Settings (LEDA) cohort by Renata Juknevičienė; Justas Simonavičius; Aurimas Mikalauskas; Kamilė Čerlinskaitė-Bajorė; Mattia Arrigo; Vytautas Juknevičius; Irina Alitoit-Marrote; Denis Kablučko; Loreta Bagdonaitė; Dalius Vitkus; Mindaugas Balčiūnas; Gitana Zuozienė; Jūratė Barysienė; Diana Žaliaduonytė; Kęstutis Stašaitis; Aušra Kavoliūnienė; Alexandre Mebazaa; Jelena Čelutkienė is a Medicine article available to read on EtoBox.

What is Soluble CD146 in the detection and grading of intravascular and tissue congestion in patients with acute dyspnoea: analysis of the prospective observational Lithuanian Echocardiography Study of Dyspnoea in Acute Settings (LEDA) cohort about?

## Objectives To evaluate the potential of soluble cluster of differentiation 146 (sCD146) in the detection and grading of congestion in patients with acute dyspnoea. ## Design Subanalysis of the prospective observational Lithuanian Echocardiography Study of Dyspnoea in Acute Settings (LEDA) cohort. ## Setting Two Lithuanian university centres. ## Participants Adult patients with acute dyspnoea admitted to the emergency department. ## Methods Congestion was assessed using clinical and sonographic parameters. All patients underwent sCD146 and N-terminal pro-B-type natriuretic peptide (NT-proBNP) testing. ## Results The median value of sCD146 concentration in the study cohort (n=437) was 405 (IQR 315–509) ng/mL. sCD146 was higher in patients with peripheral oedema than in those without (median (IQR) 472 (373–535) vs 400 (304–501) ng/mL, p=0.009) and with pulmonary rales than in those without (439 (335–528) vs 394 (296–484) ng/mL, p=0.001). We found a parallel increase of estimated right atrial pressure (eRAP) and sCD146 concentration: sCD146 was 337 (300–425), 404 (290–489) and 477 (363–572) ng/mL in patients with normal, moderately elevated and high eRAP, respectively (p=0.001). In

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Author

Renata Juknevičienė; Justas Simonavičius; Aurimas Mikalauskas; Kamilė Čerlinskaitė-Bajorė; Mattia Arrigo; Vytautas Juknevičius; Irina Alitoit-Marrote; Denis Kablučko; Loreta Bagdonaitė; Dalius Vitkus; Mindaugas Balčiūnas; Gitana Zuozienė; Jūratė Barysienė; Diana Žaliaduonytė; Kęstutis Stašaitis; Aušra Kavoliūnienė; Alexandre Mebazaa; Jelena Čelutkienė

Publisher

BMJ

Published

2022

Language

EN

Field

Medicine (Health Sciences)