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Detection and Imaging of Small Molecules of Biological Significance by Alexander P. Demchenko is a book available to read on EtoBox.

What is Detection and Imaging of Small Molecules of Biological Significance about?

Small biology-related molecules that are neutral or without a high charge density require special methods for their detection that will be highlighted in the present chapter. Due to small strength and number of potential contacts with the sensor, molecular recognition may not be very efficient, and their detection can be based on chemodosimetry concept. Many of these compounds possess specific reactivity that is the basis of their function, and this reactivity can be used to chemically modify the sensor for providing analytical signal. Here, the basic principles in the design of such sensors and the construction of smart molecular sensors and nanosensors that are able to detect multiple analytes is discussed.Recognition of small neutral or charge-distributed organic molecules in solutions and, especially, in biological media is a much greater challenge than the recognition of ionic species because the pattern of involved forces (electrostatic and Van der Waals interactions, hydrogen bonds) is much smaller and these interactions are commonly weaker. This creates problems in application of affinity sensing based on molecular recognition concept. However, in many cases one may design

Author

Alexander P. Demchenko

Publisher

Springer International Publishing Springer

Published

2023

Language

EN

ISBN

9783031190889

Subjects

Science, Chemistry, Medical