Opening book details…
Can I read Adverse prognostic impact of CD36 and CD2 expression in adult de novo acute myeloid leukemia patients on EtoBox?
Adverse prognostic impact of CD36 and CD2 expression in adult de novo acute myeloid leukemia patients by G. Perea; A. Domingo; N. Villamor; C. Palacios; J. Juncà; P. Torres; A. Llorente; C. Fernández; M. Tormo; M.P. Queipo de Llano; J. Bargay; M. Gallart; L. Florensa; P. Vivancos; J.M. Martí; Ll. Font; J. Berlanga; J. Esteve; J. Bueno; J.M. Ribera; S. Brunet; J. Sierra; J.F. Nomdedéu is a Medicine article available to read on EtoBox.
What is Adverse prognostic impact of CD36 and CD2 expression in adult de novo acute myeloid leukemia patients about?
## Background and objectives: A consecutive series of acute myeloid leukemias (aml) patients was analyzed in conditions which reduce the inter-assay variations (the same flow cytometer, the same observers and the same panel of monoclonal antibodies) in order to investigate the prognostic information provided by flow cytometry. ## Design and methods: Two hundred and sixty-six bone marrow (bm) samples from 326 patients enrolled in the lma-99 protocol from the cetlam group were studied by multiparametric flow cytometry. immunophenotyping studies were performed on erythrocyte-lysed bm samples. antigen expression of leukemic cells was analyzed using triple stainings with fluorochrome-conjugated combinations of monoclonal antibodies. ## Results: Cd2 was positive in 21 cases (8%); an associated inv(16) was detected in eight cd2+ cases (38%). two-year overall survival (os) rate for cd2+/inv(16)+ patients was 75%, whereas it was 0% for cd2+/inv(16)- patients and 47% for cd2- patients (p=0.0001). cd36 was expressed in 37% of patients (n=98). two-year leukemia-free survival (lfs) rate was 34% for cd36+ patients and 55% for cd36- patients (p=0.001). in the multivariate analysis, cd2+ (rr=8.4;
Who reads Adverse prognostic impact of CD36 and CD2 expression in adult de novo acute myeloid leukemia patients?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- G. Perea; A. Domingo; N. Villamor; C. Palacios; J. Juncà; P. Torres; A. Llorente; C. Fernández; M. Tormo; M.P. Queipo de Llano; J. Bargay; M. Gallart; L. Florensa; P. Vivancos; J.M. Martí; Ll. Font; J. Berlanga; J. Esteve; J. Bueno; J.M. Ribera; S. Brunet; J. Sierra; J.F. Nomdedéu
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0145-2126)
- Published
- 2005
- Language
- EN
- Field
- Medicine (Health Sciences)