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Mesona chinensis Benth polysaccharides protect against oxidative stress and immunosuppression in cyclophosphamide-treated mice via MAPKs signal transduction pathways by Lixin Huang; Mingyue Shen; Ting Wu; Yue Yu; Qiang Yu; Yi Chen; Jianhua Xie is a Materials Science article available to read on EtoBox.

What is Mesona chinensis Benth polysaccharides protect against oxidative stress and immunosuppression in cyclophosphamide-treated mice via MAPKs signal transduction pathways about?

In this study, the immune responses of Mesona chinensis Benth polysaccharides (MP) in vitro and in vivo were investigated. Results showed that MP presented immunomodulatory activities on macrophages and T lymphocytes in vitro. Compared with the cyclophosphamide (Cy)-induced immunosuppressive mice, the body weights, spleen indexes (3.45 to 4.91) and thymus indexes (0.78 to 1.04) of the mice treated with MP were increased, and the peripheral blood levels were recovered. MP treatment also increased superoxide dismutase, glutathione peroxidase and catalase activities, and reduced malondialdehyde levels to enhance the total antioxidant capacity of Cy-treated mice. In addition, MP significantly elevated IL-2, NO, and IFN-γ secretions of splenic lymphocytes and spleen, while MP mainly exerts an immune effect by regulating T lymphocytes. Furthermore, MP possessed the immunomodulatory activity by up-regulating the phosphorylation levels of proteins factors (c-Jun N-terminal kinase, extracellular regulated protein kinase and p38 kinase) in mitogen activated protein kinases signaling pathways. This study suggested that MP may be explored as a natural immune stimulant for functional food and n

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Author

Lixin Huang; Mingyue Shen; Ting Wu; Yue Yu; Qiang Yu; Yi Chen; Jianhua Xie

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0141-8130)

Published

2020

Language

EN

Field

Materials Science (Physical Sciences)