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Can I read 1 H -Indazole and 2 H -indazole derivatives of androsta-5,16-dien-3β-ol on EtoBox?
1 H -Indazole and 2 H -indazole derivatives of androsta-5,16-dien-3β-ol by Manuela Ramos Silva; Vânia M. Moreira; Cláudia Cardoso; Ana Matos Beja; Jorge A. R. Salvador is a Chemistry article available to read on EtoBox.
What is 1 H -Indazole and 2 H -indazole derivatives of androsta-5,16-dien-3β-ol about?
androsta-5,16-dien-3-ol, (I), and 17-(2H-indazol-2-yl)androsta-5,16-dien-3-ol, (II), both C 26 H 32 N 2 O, have an indazole substituent at the C17 position. The six-membered B ring of each compound assumes a half-chair conformation. A twist of the steroid skeleton is observed and reproduced in quantum-mechanical ab initio calculations of the isolated molecule using a molecular orbital Hartree-Fock method. In the 1H-indazole derivative, (I), the molecules are joined in a head-to-head fashion via O-HÁ Á ÁO hydrogen bonds, forming chains along the a axis. In the 2Hindazole derivative, (II), the molecules are joined in a head-totail fashion with one of the N atoms of the indazole ring system acting as the acceptor. The hydrogen-bond pattern consists of zigzag chains running along the b axis. Substituted steroids have proven to be effective in inhibiting androgen biosynthesis through coordination of the Fe atoms of some enzymes, and this study shows that indazole-substituted steroids adopt twisted conformations that restrict their intermolecular interactions.
Who reads 1 H -Indazole and 2 H -indazole derivatives of androsta-5,16-dien-3β-ol?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Manuela Ramos Silva; Vânia M. Moreira; Cláudia Cardoso; Ana Matos Beja; Jorge A. R. Salvador
- Publisher
- International Union of Crystallography; Blackwell Publishing Inc.; International Union of Crystallography (IUCr); Wiley (ISSN 0108-2701)
- Published
- 2008
- Language
- EN
- Field
- Chemistry (Physical Sciences)