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Andrographolide and Its 14-Aryloxy Analogues Inhibit Zika and Dengue Virus Infection by Li, Feng; Khanom, Wipaporn; Sun, Xia; Paemanee, Atchara; Roytrakul, Sittiruk; Wang, Decai; Smith, Duncan R.; Zhou, Guo-Chun is a Chemistry article available to read on EtoBox.

What is Andrographolide and Its 14-Aryloxy Analogues Inhibit Zika and Dengue Virus Infection about?

Andrographolide is a labdene diterpenoid with potential applications against a number of viruses, including the mosquito-transmitted dengue virus (DENV). In this study, we evaluated the anti-viral activity of three 14-aryloxy analogues (ZAD-1 to ZAD-3) of andrographolide against Zika virus (ZIKV) and DENV. Interestingly, one analogue, ZAD-1, showed better activity against both ZIKV and DENV than the parental andrographolide. A two-dimension (2D) proteomic analysis of human A549 cells treated with ZAD-1 compared to cells treated with andrographolide identified four differentially expressed proteins (heat shock 70 kDa protein 1 (HSPA1A), phosphoglycerate kinase 1 (PGK1), transketolase (TKT) and GTP-binding nuclear protein Ran (Ran)). Western blot analysis confirmed that ZAD-1 treatment downregulated expression of HSPA1A and upregulated expression of PGK1 as compared to andrographolide treatment. These results suggest that 14-aryloxy analogues of andrographolide have the potential for further development as anti-DENV and anti-ZIKV agents.

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Author

Li, Feng; Khanom, Wipaporn; Sun, Xia; Paemanee, Atchara; Roytrakul, Sittiruk; Wang, Decai; Smith, Duncan R.; Zhou, Guo-Chun

Publisher

Molecular Diversity Preservation International; MDPI AG; Multidisciplinary Digital Publishing Institute (MDPI); Berlin: Springer, 1996-; Basel: 1997-; Springer Science and Business Media LLC (ISSN 1420-3049)

Published

2020

Language

EN

Field

Chemistry (Life Sciences)