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Development of the rat salivary glands. I. Accumulation of parotid gland DNase activity by William D. Ball is a Environmental Science article available to read on EtoBox.

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The parotid gland of the rat contains high levels of a secretory DNase with a substrate preference for native DNA, requirement for divalent cations (Mg+ +) and pH optimum at 7.5. This enzyme appears not to be found i n the submaxillary-sublingual gland complex, which has only a low level of DNase activity with a contrasting substrate preference for denatured DNA. Neonatal submaxillary and parotid glands both contain a constant, low level of activity which is similar in magnitude to that of the adult submaxillary gland. DNase activity in the neonatal parotid begins to increase between 10-and 15-days post-partum and rises 10,000-fold by 30-days. The substrate preference of the low DNase activity present in the parotid gland prior to ten days was determined for newborn rats, and was found similar to the adult submaxillary rather than to the adult parotid enzyme, since the newborn extract preferentially hydrolyzed denatured DNA. These results support the working hypotheses; that the parotid gland DNase is not found in the other salivary glands and is thus a specific marker of parotid differentiation, and that the synthesis of this enzyme in the parotid gland does not begin until after

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Author

William D. Ball

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-104X)

Published

1971

Language

EN

Field

Environmental Science (Life Sciences)