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Treatment of Parkinson’s Disease with Cognitive Impairment: Current Approaches and Future Directions by Sun, Chichun (author);Armstrong, Melissa J. (author) is a Psychology article available to read on EtoBox.

What is Treatment of Parkinson’s Disease with Cognitive Impairment: Current Approaches and Future Directions about?

Cognitive impairment risk in Parkinson’s disease increases with disease progression and poses a significant burden to the patients, their families and society. There are no disease-modifying therapies or preventative measures for Parkinson’s disease mild cognitive impairment (PD-MCI), or Parkinson’s disease dementia (PDD). This article reviews current and previously investigated treatments and those under investigation, including pharmacologic, non-pharmacologic and surgical procedures. There are currently no effective pharmacologic or non-pharmacologic treatments for PD-MCI. The only recommended treatment for PDD currently is rivastigmine, a cholinesterase inhibitor. Donepezil and galantamine—other cholinesterase inhibitors—are possibly useful. Memantine, a N-methyl-D-aspartate (NMDA) receptor antagonist, is considered investigational in PDD. Drug repurposing (atomoxetine, levodopa, insulin, atomoxetine for PD-MCI; ambroxol and ceftriaxone for PDD) and novel medications (SYN120, GRF6021, NYX-458 for PD-MCI; ANAVEX2-73, LY3154207, ENT-01, DAAOI-P for PDD) currently have insufficient evidence. There is growing research supporting exercise in the treatment of PD-MCI, but most non-pha

Who reads Treatment of Parkinson’s Disease with Cognitive Impairment: Current Approaches and Future Directions?

Author

Sun, Chichun (author);Armstrong, Melissa J. (author)

Publisher

MDPI AG

Published

2021

Language

EN

Field

Psychology (Social Sciences)