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Pituitary Tumours Are Multiclonal from the Outset: Evidence from a Case with Dural Metastases by H. Buch; T. El-Hadd; J. Bicknell; D. J. Simpson; W. E. Farrell; R. N. Clayton is a Medicine article available to read on EtoBox.

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## Summary In 1992 a 54‐year‐old man underwent transsphenoidal adenomectomy to remove a clinically nonfunctioning pituitary adenoma during which there was a transient cerebrospinal fluid (CSF) leak. He received radiotherapy to a small residual remnant. Follow‐up magnetic resonance imaging (MRI) scan in 1997 showed an increase in the tumour in the pituitary stalk region and an additional intradural lesion at C1 level. In the absence of neurological symptoms and signs, an observational policy was followed. By 1999 the cervical dural lesion had enlarged and laminectomy was performed, during which three intradural lesions were removed. Histology and immunohistochemistry of the metastases were identical to those of the initial pituitary adenoma. Follow‐up MRI scan showed extension of the pituitary remnant above the chiasma, requiring transfrontal surgery. Operation was complicated by secondary brain haemorrhage from which the patient died. Autopsy revealed a small amount of residual tumour at the top of the stalk and several small intradural tumour nodules at the level of the foramen magnum. Genetic analysis of the initial pituitary tumour identified significant allelic losses in keepin

Who reads Pituitary Tumours Are Multiclonal from the Outset: Evidence from a Case with Dural Metastases?

Author

H. Buch; T. El-Hadd; J. Bicknell; D. J. Simpson; W. E. Farrell; R. N. Clayton

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 0300-0664)

Published

2002

Language

EN

Field

Medicine (Health Sciences)