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Aquaporin-1 and aquaporin-2 urinary excretion in cirrhosis: Relationship with ascites and hepatorenal syndrome by Christina Esteva-Font; Maria E. Baccaro; Patricia Fernández-Llama; Laia Sans; Monica Guevara; Elisabet Ars; Wladimiro Jiménez; Vicente Arroyo; Jose A. Ballarín; Pere Ginès is a Medicine article available to read on EtoBox.
What is Aquaporin-1 and aquaporin-2 urinary excretion in cirrhosis: Relationship with ascites and hepatorenal syndrome about?
Several experimental models of cirrhosis have shown dysregulation of renal aquaporins in different phases of liver disease. We investigated the urinary excretion of both aquaporin-1 and aquaporin-2 in patients with cirrhosis at different stages of the disease. Twenty-fourhour urine was collected from 11 healthy volunteers, 13 patients with compensated cirrhosis (without ascites), and 20 patients with decompensated cirrhosis (11 with ascites without renal failure and 9 with hepatorenal syndrome). Aquaporin-1 and aquaporin-2 excretion was analyzed by immunoblotting. Urinary aquaporin-2 excretion was reduced in patients with cirrhosis compared to healthy subjects. A progressive decrease in urinary aquaporin-2 excretion was observed as the severity of cirrhosis increased, from compensated cirrhosis to cirrhosis with ascites and hepatorenal syndrome. Patients with hyponatremia had lower urinary aquaporin-2 excretion than patients without hyponatremia. Vasopressin plasma level did not correlate with aquaporin-2 excretion. There were no differences between healthy subjects and patients with cirrhosis with or without ascites in urinary excretion of aquaporin-1, but urinary aquaporin-1 excr
Who reads Aquaporin-1 and aquaporin-2 urinary excretion in cirrhosis: Relationship with ascites and hepatorenal syndrome?
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- Author
- Christina Esteva-Font; Maria E. Baccaro; Patricia Fernández-Llama; Laia Sans; Monica Guevara; Elisabet Ars; Wladimiro Jiménez; Vicente Arroyo; Jose A. Ballarín; Pere Ginès
- Publisher
- Ovid Technologies (Wolters Kluwer Health)
- Published
- 2006
- Language
- EN
- Field
- Medicine (Health Sciences)