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What is Glioblastoma-Infiltrating CD8+ T Cells Are Predominantly A Clonally Expanded GZMK+ Effector Population about?

This study investigates the characteristics of tumor-infiltrating lymphocytes (TIL) in glioblastoma (GBM) using multi-omics approaches, revealing a predominance of clonally expanded GZMK+ effector CD8+ T cells. The findings suggest that these GZMK+ T cells may represent an important effector subset distinct from the traditionally recognized exhausted T cells, which are less prevalent in GBM. This research provides insights into potential mechanisms of resistance to immunotherapy in GBM and highlights the ne

Author

cecilialiangyx

Language

EN