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A comparison of lesion mapping analyses based on CT versus MR imaging in stroke by Margaret J. Moore; Mark Jenkinson; Ludovica Griffanti; Hanne Huygelier; Celine R. Gillebert; Nele Demeyere is a Neuroscience article available to read on EtoBox.

What is A comparison of lesion mapping analyses based on CT versus MR imaging in stroke about?

It is commonly asserted that MRI-derived lesion masks outperform CT-derived lesion masks in lesion-mapping analysis. However, no quantitative analysis has been conducted to support or refute this claim. This study reports an objective comparison of lesion-mapping analyses based on CT- and MRI-derived lesion masks to clarify how input imaging type may ultimately impact analysis results. Routine CT and MRI data were collected from 85 acute stroke survivors. These data were employed to create binarized lesion masks and conduct lesion-mapping analyses on simulated behavioral data. Following standard lesion-mapping analysis methodology, each voxel or region of interest (ROI) were considered as the underlying “target” within CT and MRI data independently. The resulting thresholded z-maps were compared between matched CT- and MRI-based analyses. Paired MRI- and CT-derived lesion masks were found to exhibit significant variance in location, overlap, and size. In ROI-level simulations, both CT and MRI-derived analyses yielded low Dice similarity coefficients, but CT analyses yielded a significantly higher proportion of results which overlapped with target ROIs. In single-voxel simulations,

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Author

Margaret J. Moore; Mark Jenkinson; Ludovica Griffanti; Hanne Huygelier; Celine R. Gillebert; Nele Demeyere

Publisher

Pergamon Press

Published

2023

Language

EN

Field

Neuroscience (Life Sciences)