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Preparation of Shikonin Liposome and Evaluation of Its in Vitro Antibacterial and in Vivo Infected Wound Healing Activity by Gang Shu; Dan Xu; Wei Zhang; Xiaoling Zhao; Haohuan Li; Funeng Xu; Lizi Yin; Xi Peng; Hualin Fu; Li-Jen Chang; Xiao-Rong Yan; Juchun Lin is a Medicine article available to read on EtoBox.
What is Preparation of Shikonin Liposome and Evaluation of Its in Vitro Antibacterial and in Vivo Infected Wound Healing Activity about?
Background: The emergence of antibiotic resistance over the past decade has made the treatment of Staphylococcus aureus infection difficult. Burn wounds infected with methicillin-resistant S. aureus (MRSA) can cause mortality in animals. Shikonin (SH) has been reported to possess antimicrobial and anti-inflammatory properties, and is also responsible for the process of wound healing. However, the pharmacological mechanism of its wound healing process remains poorly comprehended, hence the probable mechanism deserves further investigation. Purpose: The current study was designed to develop a novel SH-liposome with improved anti-MRSA effect and to detect its beneficial wound healing effects. Study Design: In vitro antibacterial tests and in vivo infected wound healing test were conducted. Methods: SH-liposome was produced by the film formation method, and the characteristics were measured using a laser particle size analyzer, transmission electron microscopy, and the dialysis method. Additionally, in vitro antibacterial tests were conducted to investigate the antibacterial effects and the relative mechanism of SHliposome. Furthermore, the therapeutic effects and bioactivity of SH-lip
Who reads Preparation of Shikonin Liposome and Evaluation of Its in Vitro Antibacterial and in Vivo Infected Wound Healing Activity?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Gang Shu; Dan Xu; Wei Zhang; Xiaoling Zhao; Haohuan Li; Funeng Xu; Lizi Yin; Xi Peng; Hualin Fu; Li-Jen Chang; Xiao-Rong Yan; Juchun Lin
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Medicine (Life Sciences)