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Antimicrobial activities of the methanol extract and compounds from Artocarpus communis (Moraceae) by Victor Kuete; Patrick Y Ango; Ghislain W Fotso; Gilbert DWF Kapche; Jean P Dzoyem; Arlette G Wouking; Bonaventure T Ngadjui; Berhanu M Abegaz is a Medicine article available to read on EtoBox.
What is Antimicrobial activities of the methanol extract and compounds from Artocarpus communis (Moraceae) about?
## Background __Artocarpus communis__ is used traditionally in Cameroon to treat several ailments, including infectious and associated diseases. This work was therefore designed to investigate the antimicrobial activities of the methanol extract (ACB) and compounds isolated from the bark of this plant, namely peruvianursenyl acetate C (**1**), α-amyrenol or viminalol (**2**), artonin E (**4**) and 2-[(3,5-dihydroxy)-(__Z__)-4-(3-methylbut-1-enyl)phenyl]benzofuran-6-ol (**5**). ## Methods The liquid microdilution assay was used in the determination of the minimal inhibitory concentration (MIC) and the minimal microbicidal concentration (MMC), against seven bacterial and one fungal species. ## Results The MIC results indicated that ACB as well as compounds **4** and **5** were able to prevent the growth of all tested microbial species. All other compounds showed selective activities. The lowest MIC value of 64 μg/ml for the crude extract was recorded on __Staphylococcus aureus__ ATCC 25922 and __Escherichia coli__ ATCC 8739. The corresponding value of 32 μg/ml was recorded with compounds **4** and **5** on __Pseudomonas aeruginosa__ PA01 and compound **5** on __E. coli__ ATCC 8739, t
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- Author
- Victor Kuete; Patrick Y Ango; Ghislain W Fotso; Gilbert DWF Kapche; Jean P Dzoyem; Arlette G Wouking; Bonaventure T Ngadjui; Berhanu M Abegaz
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2001-; Springer Science and Business Media LLC (ISSN 1472-6882)
- Published
- 2011
- Language
- EN
- Field
- Medicine (Health Sciences)