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Hepatitis C virus screening and clinical monitoring of biomarkers in patients undergoing hemodialysis by Laura Patrícia Viana Maia; Olindo Assis Martins‐Filho; Andréa Teixeira‐Carvalho; Elaine Speziali; Rolandro Vermhren; Edson Fonseca Lira; Tatiane Amabile Lima; Wornei Silva Braga; Kátia Luz Torres; Adriana Malheiro is a Medicine article available to read on EtoBox.
What is Hepatitis C virus screening and clinical monitoring of biomarkers in patients undergoing hemodialysis about?
## Abstract In this study, 395 volunteers were enrolled to investigate the seroprevalence of hepatitis C virus, the immunological and the alanine aminotransferase (ALT) biomarkers amongst hemodialysis patients, living in Manaus, Brazil. An overall seroprevalence of 13.9% was found in the hemodialysis patients. Analysis of seroconversion patterns demonstrated that most patients with HCV seroconverted up to 10 years following the first hemodialysis session. Anti‐NS5 antibody was detectable in 60.4% of patients with HCV. A lower percentage of circulating CD3^+^ and CD4^+^ T‐cells was found in patients seronegative for HCV, whereas a higher frequency of CD8^+^ T‐cells was the hallmark of patients with HCV. An overall low activation state of monocytes and eosinophils were observed in hemodialysis patients. In contrast, a higher frequency of activated neutrophils was observed in patients with HCV, selectively in the NS5+ subgroup. All hemodialysis patients had a higher percentage of activated lymphocytes, with the higher activation state in patients with NS5− reactivity. Higher ALT levels were observed in patients with HCV, especially in the NS5+ subgroup. Interestingly, the ALT levels w
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- Author
- Laura Patrícia Viana Maia; Olindo Assis Martins‐Filho; Andréa Teixeira‐Carvalho; Elaine Speziali; Rolandro Vermhren; Edson Fonseca Lira; Tatiane Amabile Lima; Wornei Silva Braga; Kátia Luz Torres; Adriana Malheiro
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0146-6615)
- Published
- 2009
- Language
- EN
- Field
- Medicine (Health Sciences)