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Antagonism of the Stimulant and Depressant Effects of Ethanol in Rats by Naloxone by M. Prunell; J. Boada; M. Feria; M. A. Benitez is a Neuroscience article available to read on EtoBox.

What is Antagonism of the Stimulant and Depressant Effects of Ethanol in Rats by Naloxone about?

The action of naloxone (0.5 and 2 mg/kg IP) on the behavioural effects of a low (2 g/kg PO) and a high dose (4 g/kg PO) of ethanol was studied in rats. Ethanol at the low dose increased spontaneous motility, enhancing open-field external ambulations and reducing shuttle-box latency. All these effects were antagonized by naloxone. Ethanol at the high dose produced by hypomotility, decreasing open-field external ambulations and impairing shuttle-box performance. In this case, naloxone also reduced the ethanol effect, but its action was less consistent. Therefore, although mechanisms other than a specific opioid receptor blockade by naloxone must be considered, an involvement of opioid peptides in the effects of ethanol cannot be discounted.

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Author

M. Prunell; J. Boada; M. Feria; M. A. Benitez

Publisher

Springer; Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC (ISSN 0033-3158)

Published

1986

Language

EN

Field

Neuroscience (Life Sciences)