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Synthesis and Characterization of Polar Functional Group Substituted Mono- and Bis-(o-carboranyl)-1,3,5-triazine Derivatives by Chai-Ho Lee; Guo Fan Jin; Ji Ho Yoon; Young Ju Jung; Jong-Dae Lee; Sungdong Cho; Hiroyuki Nakamura; Sang Ook Kang is a Chemistry article available to read on EtoBox.
What is Synthesis and Characterization of Polar Functional Group Substituted Mono- and Bis-(o-carboranyl)-1,3,5-triazine Derivatives about?
Synthesis, structural characterization, and biological activity studies of o-carborane-substituted 1,3,5-triazines (9-12) containing polar functional groups such as methoxyethyl and t-butoxycarbonylmethyl amine units are described. De-methylation of di(methoxyethyl)amine functionalized triazines 9 and 10 resulted in the production of di(hydroxyethyl)amine derivatives 13 and 14. NMR ( 1 H and 13 C) and X-ray crystallographic studies confirmed the structures derived from the sequential o-carborane substitution on the 1,3,5-triazine core. Preliminary in vitro studies revealed that compounds 9, 10, 13, and 14, despite their low cytotoxicity, accumulated at high levels in B-16 melanoma cells.
Who reads Synthesis and Characterization of Polar Functional Group Substituted Mono- and Bis-(o-carboranyl)-1,3,5-triazine Derivatives?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Chai-Ho Lee; Guo Fan Jin; Ji Ho Yoon; Young Ju Jung; Jong-Dae Lee; Sungdong Cho; Hiroyuki Nakamura; Sang Ook Kang
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0040-4039)
- Published
- 2008
- Language
- EN
- Field
- Chemistry (Physical Sciences)