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Genetic architecture of reciprocal CNVs by Christelle Golzio; Nicholas Katsanis is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Genetic architecture of reciprocal CNVs about?

Copy number variants (CNVs) represent a frequent type of lesion in human genetic disorders that typically affects numerous genes simultaneously. This has raised the challenge of understanding which genes within a CNV drive clinical phenotypes. Although CNVs can arise by multiple mechanisms, a subset is driven by local genomic architecture permissive to recombination events that can lead to both deletions and duplications. Phenotypic analyses of patients with such reciprocal CNVs have revealed instances in which the phenotype is either identical or mirrored; strikingly, molecular studies have shown that such phenotypes are often driven by reciprocal dosage defects of the same transcript. Here we explore how these observations can help the dissection of CNVs and inform the genetic architecture of CNV-induced disorders.

Who reads Genetic architecture of reciprocal CNVs?

Author

Christelle Golzio; Nicholas Katsanis

Publisher

Elsevier BV

Published

2013

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)