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Nerve Growth Factor Increases Airway Responses and Decreases Levels of Exhaled Nitric Oxide During Histamine Challenge in an in Vivo Guinea‐pig Model by S. G. Friberg; C. Olgart Höglund; L. E. Gustafsson is a Medicine article available to read on EtoBox.

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There is a growing body of evidence supporting the idea that nerve growth factor (NGF) may be involved in the development of asthma‐associated symptoms, such as airway hyper‐responsiveness. Increased levels of NGF have recently been described in serum and in the airways of asthmatics. We have examined whether exhaled nitric oxide (NO) levels might be altered during the increased airway responses upon NGF treatment in guinea‐pigs __in vivo__. Intravenous (i.v.) administration of histamine normally elicits a rapid peak in insufflation pressure (IP) and in exhaled NO, followed by a period of decreased concentrations of exhaled NO. Anaesthetized guinea‐pigs were pre‐treated intravenously with either saline, 4 or 80 ng kg^–1^ NGF 30 min before i.v. challenge with 16 __μ__g kg^–1^ histamine. At 80 ng kg^–1^ NGF significantly enhanced the airway obstruction caused by histamine, whereas the peak acute increase in exhaled NO was not enhanced. Following the increase, came a rapid drop, an effect enforced in the NGF treated animals. Subsequently, the time to return to 90% of resting exhaled NO was increased, from 12 min in saline‐treated animals to 48 min in NGF‐treated animals. Our data conf

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Author

S. G. Friberg; C. Olgart Höglund; L. E. Gustafsson

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0001-6772)

Published

2001

Language

EN

Field

Medicine (Life Sciences)