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Overview of Immunological Tolerance by Nikki Chauhan is a document available to read on EtoBox.
What is Overview of Immunological Tolerance about?
The document discusses the history and mechanisms of immunological tolerance. It notes that Burnet first postulated that antigens encountered during immune system development can induce tolerance, and that Medewar found neonatal mice could be tolerized to donor antigens via cell transfer. The key mechanisms of tolerance include clonal deletion of self-reactive cells in the thymus and periphery, anergy of T cells that encounter antigen without costimulation, and receptor editing of B cells to change antigen
- Author
- Nikki Chauhan
- Language
- EN