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Influence of Maternal Infection on Offspring Immune Response in Murine Larval Toxocariasis by K. Reiterová; O. Tomašovicová; P. Dubinský is a Medicine article available to read on EtoBox.

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## SUMMARY The impact of Toxocara canis infection on the proportion of CD4+ and CD8+ T splenocytes, the serum concentrations of cytokine IFN‐γ and IL‐5, and the production of Toxocara‐specific antibodies were studied in two C57BL6/J mouse groups and their offspring. The mice were infected with 1000 T. canis eggs on the day of mating (early infection) and on day 14 of pregnancy (late infection). Early infection resulted in a significant increase of CD4+ T‐cell subtype, however, a decline in CD8+ in comparison with late infection, as well as with non‐infected control. The IFN‐γ serum concentrations decreased in infected mothers after the birth when compared with non‐infected mothers, while in the offspring this cytokine was barely or not detectable. In the mothers of both infected groups, the humoral immune response included both parasite‐specific IgM and IgG2 antibodies. While IgG1 levels remained constant throughout the whole experiment in mothers with early infection, late‐infected mothers became seropositive only 3 weeks after delivery. IgM was not detectable in any offspring. Pups from early‐infected mothers had IgG1 antibodies. Conversely, IgG2 was detectable in pups of both ex

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Author

K. Reiterová; O. Tomašovicová; P. Dubinský

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; FASEB (ISSN 0141-9838)

Published

2003

Language

EN

Field

Medicine (Health Sciences)