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Early neurological deterioration in Wilson’s disease: a systematic literature review and meta-analysis by Agnieszka Antos; Anna Członkowska; Lukasz Smolinski; Jan Bembenek; Adam Przybyłkowski; Marta Skowrońska; Iwona Kurkowska-Jastrzębska; Tomasz Litwin is a Medicine article available to read on EtoBox.
What is Early neurological deterioration in Wilson’s disease: a systematic literature review and meta-analysis about?
## Introduction Neurological deterioration, soon after anti-copper treatment initiation, is problematic in the management of Wilson’s disease (WD) and yet reports in the literature are limited. The aim of our study was to systematically assess the data according to early neurological deteriorations in WD, its outcome and risk factors. ## Methods Using PRISMA guidelines, a systematic review of available data on early neurological deteriorations was performed by searching the PubMed database and reference lists. Random effects meta-analytic models summarized cases of neurological deterioration by disease phenotype. ## Results Across the 32 included articles, 217 cases of early neurological deterioration occurred in 1512 WD patients (frequency 14.3%), most commonly in patients with neurological WD (21.8%; 167/763), rarely in hepatic disease (1.3%; 5/377), and with no cases among asymptomatic individuals. Most neurological deterioration occurred in patients treated with d-penicillamine (70.5%; 153/217), trientine (14.2%; 31/217) or zinc salts (6.9%; 15/217); the data did not allow to determine if that reflects how often treatments were chosen as first line therapy or if the risk of det
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- Author
- Agnieszka Antos; Anna Członkowska; Lukasz Smolinski; Jan Bembenek; Adam Przybyłkowski; Marta Skowrońska; Iwona Kurkowska-Jastrzębska; Tomasz Litwin
- Publisher
- Springer Science and Business Media LLC
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)