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The influence of pH on urinary ionized [Ca2+]: differences between urinary tract stone formers and normal subjects by S.E.M. Langley; C.H. Fry is a Medicine article available to read on EtoBox.

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## Objective: To assess the role of ph in determining the solubility of ca2+ in urine from normal subjects and stone formers and to determine the conditions which cause the formation of crystalline products. ## Materials and methods: Urine, collected from normal subjects and urinary tract stone-formers, was used in vitro. the concentration of ionized calcium, [ca2+], and ph were measured with ion-selective electrodes and the formation of crystalline products measured as the change in turbidity of the specimen. the composition of the crystalline products was analysed by infrared spectroscopy. ## Results: The [ca2+] decreased with increasing ph and showed a biphasic relationship with a critical ph (phn) at which ca-containing precipitates appeared. compared with normal subjects, the mean (sd) value of phn was significantly lower in urine from stone-formers, at 7.67 (0.62) and 7.21 (0.54), respectively, and nearer to their voided ph of 5.92 (0.70) and 6.26 (0.71), respectively. the lower phn in stone-formers could not be explained by altered concentrations or binding properties of ca(2+)-binding ligands. phn increased after diluting the urine and the value of phn was strongly dependen

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Author

S.E.M. Langley; C.H. Fry

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 1464-4096)

Published

1996

Language

EN

Field

Medicine (Health Sciences)