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Validation of a lower radiation computed tomography enterography imaging protocol to detect Crohn's disease in the small bowel by Hassan Siddiki; Joel G. Fletcher; Amy K. Hara; James M. Kofler; Cynthia H. McCollough; Jeff L. Fidler; Luis Guimaraes; James E. Huprich; William J. Sandborn; Edward V. Loftus Jr.; Jay Mandrekar; David H. Bruining is a Medicine article available to read on EtoBox.

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## Background: The purpose was to validate a lower radiation dose computed tomography enterography (CTE) imaging protocol to detect the presence of Crohn's disease (CD) in the small bowel using two different reference standards and to identify a prediction model based on CTE signs for the presence of active CD. Methods: This retrospective study included patients with known or suspected CD who underwent CTE between January and October 2006 according to a lower radiation dose protocol. Two gastrointestinal radiologists blindly and independently classified each CTE as being active or inactive. Reference standards included ileocolonoscopy 6 biopsy and a comprehensive clinical reference standard (retrospectively created by a gastroenterologist, also including history, physical, follow-up course, and subsequent endoscopy, imaging, or surgery). Logistic regression was used to identify CTE findings that predicted the presence of active CD based on the combined clinical reference standard. Results: In all, 137 patients underwent CTE and ileocolonoscopy. Using an endoscopic reference standard, the sensitivity of CTE to detect active CD for the two readers was 81% and 89%, respectively. Using

Who reads Validation of a lower radiation computed tomography enterography imaging protocol to detect Crohn's disease in the small bowel?

Author

Hassan Siddiki; Joel G. Fletcher; Amy K. Hara; James M. Kofler; Cynthia H. McCollough; Jeff L. Fidler; Luis Guimaraes; James E. Huprich; William J. Sandborn; Edward V. Loftus Jr.; Jay Mandrekar; David H. Bruining

Publisher

John Wiley and Sons; Oxford University Press; Oxford University Press (OUP) (ISSN 1078-0998)

Published

2011

Language

EN

Field

Medicine (Health Sciences)